Regulation of luteolytic prostaglandin F©́ secretion in swine by Shawn Susan Whiteaker

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  • Prostaglandins.

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Statementby Shawn Susan Whiteaker.
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Paginationviii, 119 leaves, bound :
Number of Pages119
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Open LibraryOL14708451M

Download Regulation of luteolytic prostaglandin F©́ secretion in swine

Acquisition of luteolytic capacity in pigs and other mammals is associated with changes in the PGF2α-induced transcriptional regulation of key genes involved in luteal function. It is logical that key transcriptional factors, such as the AP-1 factors, are not induced in CL without luteolytic capacity and that this would result in lack of Cited by: Patek CE, Watson J.

Prostaglandin F and progesterone secretion by porcine endometrium and corpus luteum in vitro. Prostaglandins. ; – Rexroad CE, Guthrie HD. Prostaglandin F 2α and progesterone release in vitro by ovine luteal tissue during induced luteolysis.

Adv Cited by:   In swine, the mechanism by which the embryo blocks the luteolytic effect of PGF2α is based on the blastocysts secreting estradiol which, in concert with prolactin, redirects the endometrial secretion of PGF2α into the uterine lumen rather than the uterine vein. So, in contrast to ruminants, the luteolytic signal is produced by pregnant Cited by: The marked increase in P secretion between days 12 and 15 of normal pregnancy may thus be a response to intraluteal estrogen; the pattern of P secretion from day 12 to term may reflect the effects.

Oxytocin (OT) stimulates endometrial secretion of prostaglandin (PG) F 2α during corpus luteum regression in swine but there is differential responsiveness to OT among endometrial cell types.

To determine if progesterone influenced responsiveness of luminal epithelial, glandular epithelial, and stromal cells to nM OT during luteolysis in swine, cells were isolated from endometrium of 15 Cited by:   When administered systemically, oxytocin (OT) stimulates secretion of uterine prostaglandin F 2α (PGF 2α) in swine, but the role of endometrially-derived OT in control of PGF 2α release is not clear.

This study determined the effect of exogenous OT, administered into the uterine lumen of intact cyclic gilts, on PGF 2α secretion during late diestrus. Intrauterine infusion of 40 USP. In swine, episodic release of prostaglandin (PG) F2α is responsible for corpus luteum (CL) regression, but the stimulus for its secretion from the endometrium has not been established.

Order Number Leukocyte regulation of porcine luteal function Hehnke, Karen Elaine, Ph.D. Iowa State University, UMI N. Zeeb Rd. Mirando MA, Prince BC, Tysseling KA, Carnahan KG, Ludwig TE, Hoagland TA, Crain RC () A proposed role for Regulation of luteolytic prostaglandin F©́ secretion in swine book in regulation of endometrial prostaglandin F 2α secretion during luteolysis in swine.

Adv Exp Med Biol – PubMed Google Scholar. Audio Books & Poetry Community Audio Computers, Technology and Science Music, Arts & Culture News & Public Affairs Non-English Audio Spirituality & Religion.

Librivox Free Audiobook. Conversations with Selwyn BRANDfamily AudioRoom: New Writing from. The luteolytic action of prostaglandin F 2α (PGF 2α), keto-PGF 2α, methyl-PGF 2α, and cloprostenol was evaluated in cycling gilts and sows after intramuscular injection on day 13 of the estrous cloprostenol significantly shortened the mean cycle length ( vs.

d, P. A study of prostaglandin F2a as the luteolysin in swine: 1. Effect of prostaglandin F2a in hysterectomized gilts. Prostaglandins,3. Gleeson, A. R., G. Thorburn and R. Cox. Prostaglandin F concentrations in the utero-ovarian vein plasma of tire sow during the late luteal phase of the oestrous cycle.

Prostaglandins, Until the last two decades, virtually nothing was known of the mechanisms of luteolysis or of the agents that regulate such processes. It was the pioneering work of researchers at the Upjohn Company which led to the finding that prostaglandin (PG) F 2α was luteolytic in the laboratory rat (1).

This eicosanoid produces luteal regression in a. Prostaglandin also stimulates further oxytocin release, stimulating more oxytocin receptors that cause further prostaglandin F2a release. This is known as a positive cascade system and is used to quickly progress a biological situation, here the situation would be the prevention of inhibition of progesterone (which is inhibiting GnRH secretion).

Prostaglandin F2α (PGF2α) is a main luteolytic factor in vivo; however, its direct luteolytic influence on steroidogenic cells of bovine corpus luteum (CL) is controversial and not fully understood. Abstract. The pig corpora lutea (CL) acquires luteolytic capacity at about Day 13 of the estrous cycle, after which luteolysis occurs in response to prostaglandin F 2α (PGF 2α) postulated that differences in transcription factors such as the steroid hormone receptors may be responsible for the differences in PGF 2α-induced gene expression after acquisition of luteolytic.

Oxytocin (OT) stimulates endometrial secretion of prostaglandin (PG) F2 alpha around the time of corpus luteum regression in ruminants, but the stimulus for luteolytic PGF2 alpha release in cyclic.

Abstract. The ovary is concerned with the secretion of steroid hormones and with the release of a mature ovum (ovulation). Ovarian function is controlled by hormones secreted by the anterior pituitary gland, namely follicle-stimulating hormone (FSH), luteinizing hormone (LH), and, to a greater or lesser extent depending upon the species, prolactin.

luteolytic PGF 2 pulses in ewes Subluteolytic Luteolytic. Temporal and tissue-specific expression of prostaglandin receptors PGE: EP2, EP3, EP4 (not expressed in cow) PGF: FP Cyclooxygenases 1 and 2 in uterus and fetal membranes. Corporal Lutea of Pigs •FP/cell –Days Mean of–Days Mean of 2, Hysterectomy of nongravid pigs during the early part of the estrous cycle sustains luteal function until about day and relaxin and progesterone lev­ els in peripheral blood show the same secretion patterns as those of the preg­ nant pigs at comparable stages.

Prostaglandin F[sub 2a]-RmRNA levels were found to be inversely related to progesterone and estradiol production. In conclusion, PGF[sub 2a] is a multi-functional hormone which acts through complex signal transduction pathways and interactions with confounding hormones, to exert both luteotrophic and luteolytic effects.

Cite this chapter as: Torjesen P.A., Aakvaag A. () Effects of Prostaglandin F 2α on Adenylyl Cyclase Activity and Steroid Secretion in the Superluteinized Rat Ovary.

In: McKerns K.W., Aakvaag A., Hansson V. (eds) Regulation of Target Cell Responsiveness. The mechanism for the luteolytic release of prostaglandin (PG)F 2α in swine is not known. This study examined the potential role of oxytocin (OT)-induced phosphoinositide (PI) hydrolysis in promoting PGF 2α secretion in vitro from the endometrium of cyclic gilts on Day 15 postestrus.

In Experiment 1, endometrial PI hydrolysis was increased (P. Abstract. The hypothesis that prolactin exerts a stimulatory dominance over the luteolytic effect of prostaglandin (PG) F2α on corpus luteum maintenance and pr.

Prostaglandin F2a regulation of mRNA for activating protein 1 transcriptional factors in porcine corpora lutea (CL): lack of induction of JUN and JUND in CL without luteolytic capacity.

Domestic Anim Endocrinol. ;– The role of oxytocin (OT) in the regulation of prostaglandin F 2α (PGF 2α) secretion during luteolysis in gilts was studied using a highly specific OT antagonist (CAP).In Experiment 1 gilts on Days 14 to 19 of the oestrous cycle in Latin square design were used.

Free Online Library: Expression and regulation of prostaglandin transporters, ATP-binding cassette, subfamily C, member 1 and 9, and solute carrier organic anion transporter family, member 2A1 and 5A1 in the uterine endometrium during the estrous cycle and pregnancy in pigs.(Report) by "Asian - Australasian Journal of Animal Sciences"; Agricultural industry Biological.

OT receptor density was significantly correlated with the ability of nM OT to stimulate PI hydrolysis (r =p secretion (r =p. To date, the study of prostaglandin F[subscript]2[alpha] (PGF[subscript]2[alpha])-induced luteal regression has been complicated by the inability of PGF[subscript]2[alpha] to kill luteal cells in in vitro systems and the unknown influences of extrinsic factors resulting from systemic PGF[subscript]2[alpha] treatment during in vivo experimentation.

A unique intraluteal implant system solves. similar in hysterectomized and pregnant pigs from day 99 until parturition, but thereafter were consistently greater in lactating than in hysterectomized pigs (4). The uterus is a major site of prostaglandin production and luteolytic action. Prostaglandins are known to play an important role in parturition in several mammalian species.

Hixon JE, Flint AP () Effects of a luteolytic dose of oestradiol benzoate on uterine oxytocin receptor concentrations, phosphoinositide turnover and prostaglandin F- 2 alpha secretion in sheep.

J Reprod Fertil – PubMed CrossRef Google Scholar. The dynamics of PGF secretion are altered in pregnancy because E2- and OXT-induced secretion of PGF is suppressed (Figure 1).

In pregnant cows, luteolytic pulses of PGF are abolished, but there is an increase in basal secretion of PGF (Thatcher et al., ; Mishra et al., ).

Fourteen does received vaginal sponges impregnated with 40 mg fluorogestone acetate for 12 days, and a luteolytic dose of a prostaglandin analogue (75 mu g of D-cloprostenol) 2 days before sponge. Regulation and Function of Gonadotropins Throughout the Bovine Oestrous Cycle.

GnRH was first isolated from the hypothalamus of pigs and is a decapeptide [2, 3]. sufficient quantities, luteolysis of the CL occurs. PGF is secreted by the uterus in the bovine and is the major luteolytic hormone in ruminants.

Prostaglandin F2α (PGF) is the primary factor responsible for inducing luteolysis in many species, including pigs [1–3]. Initiation of luteolysis follows PGF binding to a seven-transmembrane G protein-coupled receptor called the FP receptor [ 5 ].

To summarize luteal function during pregnancy briefly, there are physiological processes initiated by the embryo and/or conceptus in early pregnancy that serve to prolong the life-span of the corpu. Luteolysis (also known as luteal regression) is the structural and functional degradation of the corpus luteum (CL), which occurs at the end of the luteal phase of both the estrous and menstrual cycles in the absence of domestic animals, luteolysis is initiated by the hormones prostaglandin F2alpha and sheep, communication between the pars nervosa (posterior lobe of.

Prostaglandins primarily of uterine origin play an important role in parturition. Hysterectomy of nongravid pigs early in the luteal phase maintains luteal function until about daywhereas the duration of normal pregnancy is about days.

Precisely timed peak release of relaxin and coincident decrease in progesterone secretion occur in unmated hysterectomized gilts similar to that found. regulation of pulsatile uterine prostaglandin f 2α secretion A.

Role of the Central Oxytocin Pulse Generator Although it was established that estrogen and progesterone indirectly control endometrial PGF 2α secretion by regulating the formation of oxytocin receptors in several nonprimate species, the regulation of systemic oxytocin during the.

Endometrial oxytocin receptors (OXTR) and prostaglandin-endoperoxide synthase 2 (PTGS2) are central components of the luteolytic pathway in cyclic mares, and their suppression is thought to be critical to luteal maintenance during early pregnancy.

We examined the effect of pregnancy on endometrial expression of potential regulators of prostaglandin (PG) F2α secretion in mares.

LH directly stimulates the secretion of progesterone from small luteal cells via activation of the protein kinase A second messenger pathway. Large luteal cells are of granulosal cell origin and contain receptors for PGF 2α and appear to mediate the luteolytic actions of this hormone.

If pregnancy does not occur, the corpus luteum must regress.In pigs, IL1β stimulates myometrial synthesis and secretion of PGF 2 α and PGE 2 on days 10 to 13 of both pregnancy and the oestrous cycle (Franczak et al.

). During the peri-implantation period (on days 15–16 of gestation), IL1β enhances cyclooxygenase 2 messenger RNA (mRNA) expression in the porcine myometrial tissue (Franczak et al.effects on the genital tract; and effects of cloprostenol and prostaglandin Fz, on secretion of gonadotropins.

Chapters on nonpregnant animals dealt with identification of pros- taglandin FZa as a uterine luteolytic hormone and the hormonal control of its synthesis.

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